Gene

cenpe

ID

ZDB-GENE-060929-860

Name

centromere protein E

Symbol

cenpe Nomenclature History

Previous Names

wu:fc06a10
zgc:152925 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have ATPase activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement and mitotic metaphase plate congression. Predicted to localize to kinesin complex and microtubule. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Yu et al., 2020

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cenpe Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary autosomal recessive microcephaly 13	Alliance	?Microcephaly 13, primary, autosomal recessive	616051

Associated With cenpe Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR001752	Kinesin motor domain
Family	IPR027640	Kinesin-like protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Kinesin-like protein	Kinesin motor domain	Kinesin motor domain, conserved site	Kinesin motor domain superfamily	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M6YXU4 InterPro	2352
UniProtKB:A0A8M2BFG2 InterPro	2668
UniProtKB:E7F2U4 InterPro	2690
UniProtKB:A0A8M2BFG4 InterPro	2626

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cenpe-201 (1) Ensembl	Ensembl	1,481 nt	Select Tool ZFIN BLAST
mRNA	cenpe-202 (1) Ensembl	Ensembl	8,469 nt	Select Tool ZFIN BLAST
mRNA	cenpe-203 (1) Ensembl	Ensembl	514 nt	Select Tool ZFIN BLAST
mRNA	cenpe-205 (1) Ensembl	Ensembl	509 nt	Select Tool ZFIN BLAST
mRNA	cenpe-206 (1) Ensembl	Ensembl	942 nt	Select Tool ZFIN BLAST
ncRNA	cenpe-003 (1) Ensembl	Ensembl	534 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations